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CAS 357-70-0 Galantamine 

Product Name: Galantamine

Alias: Galanthamine

CAS: 357-70-0

MF: C17H22ClNO3

MW: 323.8145

Purity: 99%

MP: 119-121°C

BP: 439.3°C at 760 mmHg

FP: 219.5°C

Grade: Pharmaceutical Grade

Appearance: White Powder

Galantamine is used for the treatment of mild to moderate Alzheimer's disease and various other memory impairments, in particular those of vascular origin. In addition to uses in Alzheimer's disease, galantamine has been used to treat myasthenia, myopathy, muscular dystrophy, and sensory and motor dysfunction associated with disorders of the central nervous system. Research has indicated that galantamine may prove useful both in the treatment of organophosphate poisoning and in the treatment of autism in children and adolescents.

Side Effects

Galantamine's side effect profile was very similar to that of other cholinesterase inhibitors, with gastrointestinal symptoms being the most notable and most commonly observed. One study reports higher proportions of patients treated with galantamine experiencing nausea and vomiting as opposed to the placebo group. Another study using a dose-escalation treatment has found that incidences of nausea would decrease to baseline levels soon after each increase in administered dosage. In practice, some other cholinesterase inhibitors might be better tolerated; however, a careful and gradual titration over more than three months may lead to equivalent long-term tolerability.